The aim of this study was to investigate the beneficial effects of curcumin a natural polyphenol and metformin a common therapeutic medicine for type 2 diabetes on oxidative status in kidney of type 1 diabetic rats. Enalapril attenuates oxidative stress in diabetic rats. The reduction of the activities of the antioxidant enzymes in diabetic rats reported in our study lends further support to the hypothesis that oxidative stress in diabetes mellitus results from an impaired antioxidant system ramakrishna and jailkhani, 2008, sindhu et al. Modulatory effects of garlic, ginger, turmeric and their mixture on hyperglycaemia, dyslipidaemia and oxidative stress in streptozotocinnicotinamide diabetic rats volume 105 issue 8 hafez r. Plasma total antioxidant concentration was significantly lower in diabetic rats than in control rats p in parallel with a significant reduction in the tissue activity of mnsod. We examined whether folic acid and melatonin can reduce progression of nephropathy in rats of type 1 diabetes mellitus by controlling the.
Effects of pycnogenol treatment on oxidative stress in. Melatonin and lcarnitin improves endothelial disfunction. Moursi physiology departmentfaculty of medicinezagazig university. According to our knowledge, there is little evidence about the effect of regular exercise in the hippocampus of diabetic rats with oxidative stress and apoptosis approach. Effect of treatment with vitamin d plus calcium on oxidative. Pycnogenol treatment significantly reduced blood glucose concentrations in diabetic rats. Recent evidence strongly suggests that oxidative stress due to redox imbalance is causally associated with inflammatory processes and various diseases including diabetes. This study evaluated the effects of curcumin andor insulin on antioxidant enzyme activity in blood, liver, and kidney, as well as on lipid peroxidation and delta aminolevulinic dehydratase. May, 2010 several complications of diabetes mellitus dm e.
Propolis improves pregnancy outcomes and placental oxidative. Normal and diabetic rats were treated with pycnogenol 10 mgkg body weightday, ip for 14 days. Spirulina platensis alleviates the liver, brain and heart. To evaluate the role of melatonin, an antioxidant agent, in diabetic oxidative stress and vascular damage. Pdf ellagic acid alleviates hepatic oxidative stress and. Dhe staining was performed in frozen section of liver from diabetic gk rats with or without treatment. The aim of the present study was to investigate the association between hyperglycemia and myocardial infarction on cardiovascular autonomic modulation and cardiac oxidative stress profile in rats. Graviola annona muricata attenuates behavioural alterations and testicular oxidative stress induced by streptozotocin in diabetic rats. Diabetic hyperglycemia attenuates sympathetic dysfunction. Folic acid and melatonin mitigate diabetic nephropathy in. Azelnidipine prevents cardiac dysfunction in streptozotocin.
The hyperglycemia triggers several chronic diabetic complications mediated by increased oxidative stress that eventually causes diabetic nephropathy. Graviola annona muricata attenuates behavioural alterations. However, vitamin d in combination with calcium increased the. Comparative study of antidiabetic activity and oxidative.
Differential responses to blood pressure and oxidative stress in streptozotocininduced diabetic wistarkyoto rats and spontaneously hypertensive rats. Each major group was further subdivided into five subgroups and then orally supple. This study tested the hypothesis that wxkl can improve atrial remodeling in diabetic. We examined the effects of proanthocyanidin from persimmon peel, using both oligomers and polymers, against oxidative stress with elucidation of the underlying mechanisms in. Effect of ghrelin on testicular functions in streptozotocin. Biochemical markers for oxidative stress were assessed in the liver, kidney, and heart. Sirajudeen 2, md salzihan md salleh 3 and sunil gurtu 4.
This study assessed the effects of propolis alone or combined with insulin on maternal status, pregnancy outcomes and placental oxidative stress in streptozotocininduced diabetic rats. Stzdiabetic rats showed double the ros content, evaluated in the cytosolic fraction of the left ventricle vs. This hypothesis is based on reports of increased generation of reactive oxygen species ros, decreased antioxidant levels, andor impaired generation of the reduced forms of the antioxidants 2 4. Ameliorative effects of proanthocyanidin on oxidative stress. Oct 15, 2010 plasma and heart tissue markers of oxidative stress. Curcumin analog a alleviates oxidative stress by activating. Improvement of renal oxidative stress markers after ozone. Forty female rats were randomly assigned into five groups n 8group i. Plasma and heart tissue markers of oxidative stress. The present study was designed to investigate the protective effect of the aqueous extract of portulaca oleracea against hyperglycemic, oxidative damage and inflammation in the serum of streptozotocin stzinduced diabetic rats.
Oxidative stress triggers cardiac fibrosis in the heart of. Oxidative stress impairs skeletal muscle repair in diabetic rats. Inhibition of aldehyde dehydrogenase 2 by oxidative stress. The objective of this study was to evaluate the role of oxidative stress in an experimental model of streptozotocininduced diabetic nephropathy in rats. A manganese porphyrin suppresses oxidative stress and extends. Attenuation of oxidative stress and inflammation by. In the present study, the rats were divided into the following groups of 8 animals each. Oct 16, 20 this study evaluated the effects of curcumin andor insulin on antioxidant enzyme activity in blood, liver, and kidney, as well as on lipid peroxidation and delta aminolevulinic dehydratase.
Does curcumin or metformin attenuate oxidative stress and. The objectives of the present work were to study the possible effects of spi treatment on the glycemiclipid profile, oxidative stress, lipid peroxidation and cardiac performance in diabetic rats. Ozone, by means of oxidative preconditioning, may exert its protective effects on dn. The role of oxidative stress in streptozotocininduced. The effects of lemon flavonoids, as crude flavonoids prepared from lemon juice, were investigated in diabetic rats. Sodiumglucose cotransporter inhibition prevents oxidative. Protection against oxidative stress in diabetic rats by wheat.
Ea treatment reduces hepatic oxidative stress in diabetic gk rats. Oxidative stress in diabetic tissues is a consequence of free radical accumulation with concurrently impaired natural antioxidants status and results in oxidative tissue damage. Pdf the antioxidant effect of boron on oxidative stress and. Numerous evidences suggest that diabetic heart is characterized by compromised ventricular contraction and prolonged relaxation attributable to multiple causative factors including calcium accumulation, oxidative stress and apoptosis. Wenxin keli regulates mitochondrial oxidative stress and. Oxidative stress impairs skeletal muscle repair in. Modulatory effects of garlic, ginger, turmeric and their. Mp decreased oxidative stress by upregulating p in endothelium dependent relaxation induced by acetylcholine, but did not create ant change in snp induced endothelium independent relaxation in the aortas of diabetic rats. In the present study, we examined whether treadmill running could alleviate oxidative stress and apoptosis rate in the hippocampus of streptozotocin stzinduced diabetic rats. At birth, wistar rats received citrate buffer nondiabetic group, n 15 and another group received streptozotocin 100 mgkg, subcutaneous to induce mild diabetes diabetic, n 15. Effect of exercise on diabetesinduced oxidative stress in. The aim of this study was to investigate the beneficial effects of curcumin a natural polyphenol and. In rodent models of type 1 and type 2 diabetes, accumulation of triglyceride in the heart is associated with cardiac dysfunction and oxidative stress. Jun, 2014 to evaluate the role of melatonin, an antioxidant agent, in diabetic oxidative stress and vascular damage.
Evidence of oxidative stress and mitochondrial dysfunctions. Twentyfour rats were divided into the following groups. Diabetic hyperglycemia attenuates sympathetic dysfunction and. A manganese porphyrin suppresses oxidative stress and. Pdf graviola annona muricata attenuates behavioural.
An investigation was made of the effects of sdg on the development of diabetes in diabetic prone biobreeding rats bbdp rats, a model of human type i diabetes insulin dependent diabetes mellitus iddm to determine if this type of diabetes is due to oxidative stress and if sdg can prevent the incidence of diabetes. In this study, the effect of reinstitution of gc on hyperglycemiainduced increased oxidative stress and nitrative stress was evaluated in the retina of rats maintained in pc before initiation of gc. Oxidative stress and nitrative stress in diabetic rats. Melatonin and lcarnitin improves endothelial disfunction and oxidative stress in type 2 diabetic rats. Graviola annona muricata, a small tree of the annonaceae family, has been investigated for its protective effects against diabetic complications, oxidative stress, and neuropathies. Differential responses to blood pressure and oxidative.
The potential link between oxidative stress and agesinduced vascular calcification, however, has not been examined. Consistent with previous findings, treatment of curcumin or a in our study decreased the oxidative stress levels. This study investigated the vulnerability of immature testis to oxidative stress and mitochondrial dysfunctions in a prepubertal pp diabetic rat. Spirulina platensis alleviates the liver, brain and heart oxidative stress in type 1 diabetic rats. Objective the study evaluated the effects of vindoline on testicular and epididymal oxidative stress in diabetes induced male wistar rats. Mitochondrial dysfunction and oxidative stress play an important role in the pathogenesis of both atrial fibrillation af and diabetes mellitus dm. Previous research has demonstrated that hyperglycemia may protect the heart against ischemic injury. Our results showed that daily supplementation of vco 20% of food for 16 weeks significantly p dyslipidaemia and oxidative stress in streptozotocinnicotinamide diabetic rats volume 105 issue 8 hafez r. Oxidative stress in maternal blood and placenta from mild. The aim of this study was to examine if the sodiumglucose cotransporter sglt2 inhibition prevents the oxidative stress in the kidney of diabetic rats.
The present study investigated the protective effects of mangiferin against pancreatic. Oct 17, 2007 effect of ligninderived lignophenols on vascular oxidative stress and inflammation in streptozotocininduced diabetic rats. Research article open access advanced glycation end. The aim of the present work is to study the possible role of ozone therapy in ameliorating oxidative stress and inducing renal antioxidant defence in streptozotocin stzinduced diabetic rats. Alongside increased proteolysis, the inability to repair damaged skeletal muscle is a characteristic feature of uncontrolled diabetes. The results indicate that mniii n alkylpyridylporphyrins can be used as potent therapeutic agents in diabetes. The effect of enalapril treatment on oxidative stress and tissue injury was studied in hearts, kidneys, and livers from streptozotocininduced diabetic rats.
Table 2 shows the results of oxidative stress markers in experimental groups. Diabetes was induced in 21 male wistar rats by intraperitoneal ip administration of. Pdf lycopene attenuates diabetesinduced oxidative stress. This study was planned to investigate the effects of graviola on behavioural alterations and. Diabetes was induced by streptozotocin stz in male wistar rats. Mangiferin from salacia chinensis prevents oxidative. Attenuation of oxidative stress and inflammation by portulaca. Sulaiman 1, mohd suhaimi ab wahab 1, kuttulebbai n. Oxidative stress and diabetic complications circulation. Diabetic nephropathy is a serious kidneyrelated complication of type 1 or 2 diabetes that is prevalent in almost 40% of the people with diabetes. In the present study, both endogenous antioxidants total and non protein sulfhydryl molecules were found to be inhibited in the diabetic group. The underlying mechanisms behind the oxidative stress and the free radicals generated by diabetes have been extensively investigated 41, 57. Diabetes mellitus is a global epidemic leads to multiple serious health complications, including nephropathy. Wenxin keli wxkl, an antiarrhythmic traditional chinese medicine, has been shown to prevent cardiac arrhythmias through modulation of cardiac ion channels.
Since the importance of oxidative stress in the development of diabetic nephropathy dn has previously been established, the therapeutic effects of various natural antioxidant agents or synthetic drugs have so far been investigated. Plasma total antioxidant concentration was significantly lower in diabetic rats than in control rats p stz diabetic rats it has been proposed that reac it has been proposed that reactive oxygen species ros are increased and responsible for development of nephropathy. In this study, we evaluated whether treadmill running could alleviate oxidative stress and apoptosis rate in the hippocampus of streptozotocin induced diabetic rats. This study evaluates the role of oxidative stress in musclespecific gene regulatory regions and myosin chain synthesis in streptozotocin stzinduced diabetic and zdf rats. Comparative biochemistry and physiology part a 5 2003 539547 oxidative stress in streptozotocininduced diabetic r. In the current study, the influence of nso on pancreatic and hepatic oxidative stress was examined in the stzinduced diabetic male rats. Propolis improves pregnancy outcomes and placental. One hundred and twenty male wistar rats were divided into two healthy and diabetic groups, randomly. The aim of this study was to investigate the potential protective effect of virgin coconut oil vco on oxidative stress parameters in the liver, kidneys and heart of alloxaninduced 150 mg kg.
Oxidative stress is increased in diabetes mellitus dm. Effect of treatment with vitamin d plus calcium on. The gssg to gsh ratio increased in the stz group, indicating a decrease in gsh level and thus an imbalance in the oxidative state in the heart tissue. The aim of the present study was at evaluating the effects of oxidative stress in blood and placenta of mild diabetic wistar rats. Therapeutic interventions to prevent calcium accumulation and oxidative stress could be therefore helpful in improving the cardiac function under diabetic. Mar 12, 2009 this study investigated the vulnerability of immature testis to oxidative stress and mitochondrial dysfunctions in a prepubertal pp diabetic rat model. The protective role of virgin coconut oil on the alloxan. In this experimental study 60 male wistar rats were divided into 10 groups. This study was planned to investigate the effects of graviola on behavioural. Studies have shown that the oxidative stress level in multiple organs, including the myocardial cells, of the diabetic rats was overwhelming, as indicated by the increasing level of mda and decreasing activity of sod 7, 17, 18. The antioxidant effect of boron on oxidative stress and dna damage in diabetic rats article pdf available in fresenius environmental bulletin 2411. Inhibition of aldehyde dehydrogenase 2 by oxidative stress is. Alad activity, and a histopathological analysis of streptozotocininduced diabetic rats. We examined whether folic acid and melatonin can reduce progression of nephropathy in rats.
Ameliorative effects of proanthocyanidin on oxidative. Black seed thymoquinone improved insulin secretion. Black seed thymoquinone improved insulin secretion, hepatic. However the underlying mechanisms have not yet been evaluated. Oct 10, 2014 previous research has demonstrated that hyperglycemia may protect the heart against ischemic injury. B translocation and ameliorating oxidative stress in diabetic rats explains an associative relationship between the inflammatory cytokines and dm. In the gastrocnemius muscle of diabetic rats, prooxidant. This study tested the hypothesis that wxkl can improve atrial. Therapeutic interventions to prevent calcium accumulation and oxidative stress could be therefore helpful in improving the. The aim of the present work is to study the possible role of ozone therapy in ameliorating oxidative stress and inducing renal antioxidant defence in streptozotocin stz. Lutein dietary supplementation attenuates streptozotocin. In conclusion, melatonin therapy decreased oxidative stress and mda levels that was increased in diabetes and increased the low no levels. Methods forty male wistar rats were randomly divided into four groups n10.
Oxidative stress as a mechanism of diabetes in diabetic bb. Blood glucose levels after oral administration of lycopene in diabetic wistar rats. Male wistar rats received a high fat diet for 8 weeks followed by a single dose of streptozotocin to induce dm dm. Oxidative stress is caused by imbalance between oxidantantioxidant systems, which could be because of elevated free radical generation and decreased activity of antioxidants. Pdf the antioxidant effect of boron on oxidative stress. Jan 14, 2020 diabetes mellitus is a global epidemic leads to multiple serious health complications, including nephropathy. Oxidative stresses intensify the progression of diabetesrelated behavioural changes and testicular injuries. In humans and experimentally diabetic rats, oxidative stressmediated damage seems to be involved in the cause of diabetic complications. Pdf on may 31, 2018, daniel eze ejike and others published lycopene attenuates diabetes induced oxidative stress in wistar rats find, read and cite all the research you need on researchgate. Streptozotocin induced type 1 diabetic rats maher n. Mar 24, 2007 evaluation of oxidative stress induced diabetic complications on alloxantreated hyperglycaemic rats, using some biochemical parameters and histological profiles of three major organs.
299 1339 641 1425 562 1079 538 762 424 1473 666 1312 1196 886 1190 1247 842 213 1510 760 274 825 945 64 619 969 707 371 480 131 28